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SulbuThiamine is a precursor to thiamine (i.e., vitamin
B1). It is indicated for the condition of asthenia.[1] Furthermore, the
ability of sulbutiamine to reduce fatigue is considered desirable by
athletes, and it is available for sale as a nutritional supplement.
Additionally, the demonstrated ability of sulbutiamine to improve
memory in rats[2] and patients of schizophrenia[2] suggests that it is
a nootropic.
Contents
Effects
Sulbuhtiamine reduces fatigue, memory difficulties, intellectual tiredness and may speed convalescence.[3]
Dosage
Sulbutiamine
is sometimes supplied in 200 mg tablets. The proper therapeutic dosage
has been reported to be 12.5 mg/kg,[2] which corresponds to 850 mg for
a 68 kg (150 lb) person. However, it should be noted that dosage
recommendations vary; one manufacturer for example, recommends no more
than 600 mg per day.
Chemical data
Formula C32H46N8O6S2
Mol. mass 702.89 g/mol
Systematic (IUPAC) name
[4-[(4-amino-2-methyl-pyrimidin-5-yl)methyl-formyl- amino]-3-[2-[(4-amino-2-methyl-pyrimidin-5-yl)methyl- formyl-amino]-5-(2-methylpropanoyloxy)pent-2-en-3- yl]disulfanyl-pent-3-enyl] 2-methylpropanoate
Synonyms : sulbutiamine
Pharmacokinetic data
Half life 5 hours
References
1. ^ Shah SN; Sulbutiamine Study Group (2003). "Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia.". J Assoc Physicians India 51: 891Ð5. PMID 14710977.
2. ^ a b c Bizot JC, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H (2005). "Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task.". Prog Neuropsychopharmacol Biol Psychiatry 29 (6): 928Ð35. PMID 15951087.
3. ^ http://www.serdiapharma.com/about/arcalion.asp
As seen in
* "New Drugs that Make you Smart" by John Morgenthaler at
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